ØRheumatoid
arthritis (RA) is a chronic, systemic inflammatory disease that primarily
attacks peripheral joints and the surrounding muscles, tendons, ligaments, and
blood vessels.
ØRA
strikes women three times more often than it does men.
ØDirect
cause unknown.
Diagnostic test results
Symptoms:
Diagnostic test results
ØX-rays
show bone demineralization and soft-tissue swelling (early stages), cartilage
loss and narrowed joint spaces and, finally, cartilage and bone destruction and
erosion, subluxations, and
deformities (later stages).
ØRF titer is
positive in 75% to 80% of patients (titer of 1:160 or higher).
ØSynovial
fluid analysis shows increased volume and turbidity but decreased viscosity and
elevated white blood cell counts.
ØSerum
protein electrophoresis shows elevated serum globulin levels.
ØErythrocyte
sedimentation rate and C-reactive protein levels are elevated in 85% to 90% of
patients (may be useful to monitor response to therapy because elevation
frequently parallels disease activity).
ØComplete
blood count reveals moderate anemia, slight leukocytosis, and
slight thrombocytosis.
- fever,weight loss
- fatigue,lymphadenopathy
- malaise
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