ØHuman immunodeficiency virus (HIV) infection may cause acquired immunodeficiency syndrome (AIDS).
ØAlthough characterized by gradual destruction of cell-mediated (T cell) immunity, AIDS also affects humoral immunity and even autoimmunity through the central role of the CD4+ (helper) T lymphocyte in all immune reactions.
ØThe resulting immunodeficiency makes the patient susceptible to opportunistic infections, cancers, and other abnormalities that define AIDS.
ØHIV-1 retrovirus transmitted by contact with infected blood or body fluids
ØHomosexual or bisexual men
ØI.V. drug users
ØNeonates of infected women
ØRecipients of contaminated blood or blood products
ØHeterosexual partners of persons in high-risk groups